Face development

Across TCGA patient cohorts, RNA activity of the Face development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP16, GAPDHP28, and PPIA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Face development activity versus NOP16 in BRCA (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOP16 →	-0.287	-0.480	.002	.002	2	5
BRCA	GAPDHP28 →	-0.169	-0.484	.003	.004	3	3
BRCA	PPIA →	-0.377	-0.707	<.001	.001	3	3
COAD	SOX5 →	+0.236	+0.711	<.001	.005	2	4
COAD	IGHD →	+1.086	+0.736	.004	.002	3	3
GBM	RPL21P5 →	+0.345	+0.414	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060324 vs NOP16 — BRCA

Explore this scatter interactively →