Face development

Across TCGA cell cohorts, RNA activity of the Face development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1AKMT4, ZNF189, and ANKRD13B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EEF1AKMT4 grouped by Face development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EEF1AKMT4 →	+0.864	+1.130	.006	.005	2	5
CNS	ZNF189 →	+0.395	+0.893	<.001	<.001	3	4
OESOPHAGUS	ANKRD13B →	+1.241	+0.272	.003	<.001	3	4
PANCREAS	ZNF462 →	+1.095	+1.162	.001	<.001	3	3
KIDNEY	ABCF3 →	+0.655	+1.750	.002	<.001	3	3
OESOPHAGUS	DIO2 →	-2.758	-0.181	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EEF1AKMT4 by Face development activity — PANCREAS

Explore this box plot interactively →