Face development

Across TCGA cell cohorts, RNA activity of the Face development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCEH1, NMT2, and NPTXR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Face development activity versus NCEH1 in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NCEH1 →	+1.211	+1.068	.005	<.001	3	5
LIVER	NMT2 →	+1.898	+1.494	.001	.004	3	5
BLOOD_Myeloma	NPTXR →	+2.499	+0.310	.002	.003	3	5
BONE	NUF2 →	+0.658	+1.224	.004	.009	3	5
LIVER	RGMB →	+1.622	+1.771	.009	<.001	3	4
LIVER	USP9X →	+1.052	+1.438	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060324 vs NCEH1 — BREAST

Explore this scatter interactively →