Head morphogenesis

Across TCGA cell cohorts, RNA activity of the Head morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLF2, SYNE3, and KIN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLF2 grouped by Head morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MLF2 →	+0.580	+0.403	<.001	.002	3	4
BLOOD_Leukemia	SYNE3 →	-1.507	-0.290	.004	.003	2	5
STOMACH	KIN →	-0.712	-0.192	.003	<.001	2	4
BLOOD_Myeloma	SPCS3 →	-1.247	-1.642	.008	.009	3	3
BLOOD_Myeloma	ETV5 →	+3.339	+1.382	<.001	.008	3	3
BREAST	UXS1 →	-0.840	-0.513	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLF2 by Head morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →