Head morphogenesis

Across TCGA cell cohorts, RNA activity of the Head morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C17orf80, MEX3D, and FZD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C17orf80 grouped by Head morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C17orf80 →	-0.125	-1.287	.009	.003	3	4
LUNG_NSCLC_LUSC	MEX3D →	-0.300	-1.860	.003	<.001	3	4
LIVER	FZD3 →	-0.316	-1.632	.003	<.001	3	3
LIVER	SDF2 →	-0.253	-1.471	.009	<.001	2	4
BLOOD_Lymphoma	NEDD4L →	+0.362	+1.477	.003	<.001	3	3
BREAST	TAZ →	-0.164	-0.994	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C17orf80 by Head morphogenesis activity — CNS

Explore this box plot interactively →