Head morphogenesis

Across TCGA cell cohorts, RNA activity of the Head morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CETN2, RRAS, and GARS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Head morphogenesis activity versus CETN2 in SOFT_TISSUE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CETN2 →	+0.832	+1.447	.005	<.001	3	6
LIVER	RRAS →	+2.230	+1.694	.003	<.001	3	6
BLOOD_Lymphoma	GARS1 →	+0.755	+1.050	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	AKNA →	-0.637	-1.357	.006	<.001	3	4
LIVER	PSMD10 →	+1.817	+1.823	<.001	<.001	3	4
SOFT_TISSUE	XIAP →	+0.590	+1.426	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060323 vs CETN2 — SOFT_TISSUE

Explore this scatter interactively →