Regulation of ryanodine-sensitive calcium-release channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of ryanodine-sensitive calcium-release channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, RPS6KA3, and ZAP70, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ryanodine-sensitive calcium-release channel activity activity versus CLIC2 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLIC2 →	+0.485	+0.087	<.001	<.001	3	5
PDAC	RPS6KA3 →	+0.214	+0.046	.005	.005	2	5
LSCC	ZAP70 →	+0.406	+0.049	.001	<.001	3	4
PDAC	EIF4E3 →	+0.277	+0.051	<.001	<.001	3	4
LSCC	IL16 →	+0.456	+0.050	<.001	<.001	3	4
LSCC	INPP5D_S243 →	+0.552	+0.054	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060314 vs CLIC2 — HNSC

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