Regulation of ryanodine-sensitive calcium-release channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of ryanodine-sensitive calcium-release channel activity pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFEMP1, FLI1, and MAMDC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ryanodine-sensitive calcium-release channel activity activity versus EFEMP1 in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EFEMP1 →	+1.102	+0.997	<.001	.001	3	5
COAD	FLI1 →	+0.361	+0.603	.003	.003	3	5
UCEC	MAMDC2 →	+1.422	+1.040	<.001	<.001	3	5
HNSC	GIMAP7 →	+0.714	+0.640	.006	.003	3	5
UCEC	MEF2C-AS1 →	+0.568	+0.982	.002	<.001	3	5
COAD	CLIC2 →	+0.671	+0.821	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060314 vs EFEMP1 — COAD

Explore this scatter interactively →