Regulation of blood vessel remodeling

Across TCGA patient cohorts, RNA activity of the Regulation of blood vessel remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP39, S100A11, and RFC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood vessel remodeling activity versus USP39 in LSCC (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP39 →	-0.412	-0.094	<.001	<.001	3	6
COAD	S100A11 →	+0.383	+0.033	<.001	.003	3	5
GBM	RFC3 →	-0.242	-0.060	<.001	<.001	3	5
GBM	SF3B1 →	-0.232	-0.100	<.001	<.001	3	5
LSCC	SNRNP200 →	-0.290	-0.078	<.001	<.001	3	5
LSCC	AHCTF1_S1541 →	-0.404	-0.075	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060312 vs USP39 — LSCC

Explore this scatter interactively →