Regulation of blood vessel remodeling

Across TCGA patient cohorts, RNA activity of the Regulation of blood vessel remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD51AP1, RAPGEF3, and PBK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood vessel remodeling activity versus RAD51AP1 in OV (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAD51AP1 →	-0.576	-0.217	.002	<.001	3	4
GBM	RAPGEF3 →	+0.590	+0.181	.002	.003	3	4
LSCC	PBK →	-0.718	-0.204	.001	<.001	3	4
LSCC	ESCO2 →	-0.479	-0.202	.002	<.001	3	4
LUAD	VRK2 →	-0.233	-0.563	.003	<.001	3	4
CCRCC	LAMB2 →	+0.468	+0.453	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060312 vs RAD51AP1 — OV

Explore this scatter interactively →