Regulation of blood vessel remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of blood vessel remodeling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD68, PAIP2B, and MAPK10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD68 grouped by Regulation of blood vessel remodeling-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CD68 →	-3.679	-1.170	.002	.004	3	4
LUNG_SCLC	PAIP2B →	+2.084	+1.420	<.001	<.001	3	4
LUNG_SCLC	MAPK10 →	+2.266	+1.401	<.001	<.001	3	4
LUNG_SCLC	ANLN →	-1.411	-1.190	<.001	.002	3	4
LARGE_INTESTINE	AUH →	+0.841	+1.003	.002	.004	3	4
LUNG_SCLC	TAL2 →	+1.096	+0.923	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD68 by Regulation of blood vessel remodeling activity — STOMACH

Explore this box plot interactively →