Regulation of blood vessel remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of blood vessel remodeling pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS1, TRPV1, and ADARB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRS1 grouped by Regulation of blood vessel remodeling-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IRS1 →	+0.178	+0.456	.001	.009	3	4
BREAST	TRPV1 →	+0.192	+1.459	.004	.007	3	3
CNS	ADARB1 →	+0.335	+0.578	<.001	.004	3	3
PANCREAS	FDFT1 →	+0.217	+2.273	<.001	<.001	3	3
STOMACH	CLINT1 →	+0.356	+1.549	.005	<.001	2	3
STOMACH	RGL1 →	+0.443	+1.784	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRS1 by Regulation of blood vessel remodeling activity — OESOPHAGUS

Explore this box plot interactively →