Regulation of blood vessel remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of blood vessel remodeling pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRC2C, GLMP, and DNAJC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood vessel remodeling activity versus PRRC2C in SKIN (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRRC2C →	+0.540	+0.570	<.001	.009	2	4
SKIN	GLMP →	+2.415	+0.651	<.001	.003	3	3
LARGE_INTESTINE	DNAJC5 →	+1.116	+1.422	.002	.003	3	3
LARGE_INTESTINE	LNX2 →	+1.037	+1.493	.001	<.001	3	3
LARGE_INTESTINE	ZNF232 →	-1.158	-1.652	.001	.001	3	3
LARGE_INTESTINE	DDAH2 →	+1.418	+1.495	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060312 vs PRRC2C — SKIN

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