Regulation of ventricular cardiac muscle cell membrane repolarization

Across TCGA cell cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LARGE1, MYLIP, and ZNF502, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ventricular cardiac muscle cell membrane repolarization activity versus LARGE1 in CNS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LARGE1 →	+1.784	+1.087	.001	.002	3	5
LUNG_NSCLC_LUAD	MYLIP →	+1.272	+0.644	.004	.008	3	5
CNS	ZNF502 →	+1.510	+1.308	.003	.001	3	3
SOFT_TISSUE	C1orf226 →	+2.190	+1.487	<.001	<.001	3	3
LUNG_SCLC	SLC25A36 →	+0.710	+0.972	.003	<.001	3	3
LUNG_SCLC	ZYG11B →	+0.575	+1.032	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060307 vs LARGE1 — CNS

Explore this scatter interactively →