Regulation of membrane repolarization

Across TCGA cell cohorts, RNA activity of the Regulation of membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAVIN1, ZC3H12C, and CCDC80, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization activity versus CAVIN1 in BREAST (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAVIN1 →	+3.390	+0.265	.001	.001	3	8
BLOOD_Lymphoma	ZC3H12C →	+1.353	+0.183	<.001	.006	3	8
OESOPHAGUS	CCDC80 →	+4.098	+0.404	<.001	<.001	3	7
BLOOD_Lymphoma	NIBAN1 →	+3.909	+0.303	<.001	.001	3	7
LARGE_INTESTINE	FLNA →	+2.294	+0.324	<.001	.002	2	8
PANCREAS	FRMD6 →	+2.688	+0.449	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060306 vs CAVIN1 — BREAST

Explore this scatter interactively →