Regulation of phosphatidylinositol dephosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of phosphatidylinositol dephosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO7, CCAR2, and RPS7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatidylinositol dephosphorylation activity versus XPO7 in PDAC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	XPO7 →	+0.141	+0.031	.002	<.001	3	7
OV	CCAR2 →	+0.308	+0.039	<.001	.001	3	6
CCRCC	RPS7 →	-0.147	-0.025	<.001	.003	3	5
LSCC	FDFT1 →	+0.719	+0.046	<.001	<.001	3	5
GBM	UBE4A →	+0.163	+0.031	<.001	.007	3	5
BRCA	PPP2CB →	+0.487	+0.026	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060304 vs XPO7 — PDAC

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