Regulation of phosphatidylinositol dephosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of phosphatidylinositol dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCH1, PCDHGC5, and TRMT44, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatidylinositol dephosphorylation activity versus PLCH1 in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLCH1 →	+0.542	+0.393	.009	.003	3	3
HNSC	PCDHGC5 →	-0.549	-0.532	.007	.005	3	3
BRCA	TRMT44 →	+0.356	+0.494	.003	.002	3	3
BRCA	NDUFA11 →	+0.420	+0.612	.007	<.001	3	3
BRCA	NALT1 →	+0.654	+0.529	<.001	.002	3	3
BRCA	RPL9P31 →	+0.086	+0.593	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060304 vs PLCH1 — HNSC

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