Regulation of phosphatidylinositol dephosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of phosphatidylinositol dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY6G5C, CLDN4, and LIFR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LY6G5C grouped by Regulation of phosphatidylinositol dephosphorylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LY6G5C →	-0.664	-0.783	<.001	.002	3	4
KIDNEY	CLDN4 →	-4.100	-1.209	<.001	.002	3	4
PANCREAS	LIFR →	+1.321	+1.201	<.001	<.001	3	4
LUNG_SCLC	TMEM184A →	-3.478	-1.679	<.001	<.001	3	4
CNS	POLR1E →	+0.529	+0.846	.003	.001	3	4
SOFT_TISSUE	SAMHD1 →	+1.106	+1.080	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LY6G5C by Regulation of phosphatidylinositol dephosphorylation activity — BREAST

Explore this box plot interactively →