Positive regulation of sarcomere organization

Across TCGA patient cohorts, RNA activity of the Positive regulation of sarcomere organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKD1_S249, RSU1, and SEPTIN7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sarcomere organization activity versus PRKD1_S249 in HNSC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRKD1_S249 →	+0.723	+0.110	<.001	<.001	3	8
BRCA	RSU1 →	+0.416	+0.088	<.001	<.001	3	7
COAD	SEPTIN7 →	+0.193	+0.050	<.001	.002	3	7
COAD	SERPINF1 →	+0.664	+0.074	<.001	<.001	3	7
OV	DCHS1 →	+0.444	+0.109	<.001	<.001	3	7
COAD	PRKD1 →	+0.660	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060298 vs PRKD1_S249 — HNSC

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