Positive regulation of sarcomere organization

Across TCGA patient cohorts, RNA activity of the Positive regulation of sarcomere organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKD1, ISLR, and LMOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sarcomere organization activity versus PRKD1 in UCEC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKD1 →	+1.183	+0.960	<.001	<.001	3	7
OV	ISLR →	+1.276	+0.607	<.001	.002	3	6
BRCA	LMOD1 →	+1.368	+0.928	<.001	<.001	3	6
BRCA	JAM3 →	+0.938	+0.842	<.001	<.001	3	6
BRCA	MSRB3 →	+1.234	+0.763	<.001	<.001	3	6
BRCA	AKT3 →	+0.833	+0.708	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060298 vs PRKD1 — UCEC

Explore this scatter interactively →