Positive regulation of sarcomere organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of sarcomere organization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1C1, INO80E, and DNAJC8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V1C1 grouped by Positive regulation of sarcomere organization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ATP6V1C1 →	+1.101	+1.075	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	INO80E →	+0.953	+1.328	<.001	.005	2	6
LARGE_INTESTINE	DNAJC8 →	+0.552	+1.050	.003	<.001	3	4
BLOOD_Lymphoma	PCBD2 →	+0.997	+1.254	.001	.009	2	5
UPPER_AERODIGESTIVE_TRACT	ZWILCH →	+1.159	+1.327	.007	.005	2	5
LUNG_SCLC	RPL26L1 →	+1.340	+1.692	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V1C1 by Positive regulation of sarcomere organization activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →