Positive regulation of sarcomere organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of sarcomere organization pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMG6, SEMA5A, and ARAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMG6 grouped by Positive regulation of sarcomere organization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SMG6 →	-0.229	-1.791	.004	<.001	3	4
LARGE_INTESTINE	SEMA5A →	-0.156	-0.892	.005	.001	3	4
BREAST	ARAP2 →	+0.104	+1.026	.007	.002	3	4
LARGE_INTESTINE	BRIX1 →	-0.264	-1.133	.005	.003	3	4
OVARY	HRH4 →	+0.174	+1.174	.008	.004	3	4
CNS	CA10 →	-0.266	-1.681	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMG6 by Positive regulation of sarcomere organization activity — STOMACH

Explore this box plot interactively →