Regulation of sarcomere organization

Across TCGA cell cohorts, RNA activity of the Regulation of sarcomere organization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMD11, ANAPC1, and PSMD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMD11 grouped by Regulation of sarcomere organization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PSMD11 →	+0.770	+1.844	.003	<.001	3	5
LUNG_NSCLC_LUSC	ANAPC1 →	+1.018	+1.430	.001	.004	3	4
OESOPHAGUS	PSMD4 →	+0.381	+1.038	.002	.001	3	4
OESOPHAGUS	RBM34 →	+0.773	+1.151	.009	.002	3	4
BLOOD_Lymphoma	ATE1 →	+0.850	+1.393	.006	.001	3	4
BLOOD_Lymphoma	PPP4R3B →	+0.886	+1.890	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMD11 by Regulation of sarcomere organization activity — LIVER

Explore this box plot interactively →