Regulation of sarcomere organization

Across TCGA cell cohorts, RNA activity of the Regulation of sarcomere organization pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF764, DRAM2, and LRRC24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF764 grouped by Regulation of sarcomere organization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF764 →	+0.117	+0.462	.002	.004	3	4
STOMACH	DRAM2 →	-0.187	-0.251	.002	<.001	3	3
STOMACH	LRRC24 →	-0.252	-0.200	.001	.001	3	3
BLOOD_Lymphoma	TGM7 →	+0.310	+0.444	.006	.009	2	4
BLOOD_Lymphoma	OR14A16 →	-0.276	-0.414	.002	.005	3	3
BREAST	PDXP →	-0.175	-0.540	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF764 by Regulation of sarcomere organization activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →