Transdifferentiation

Across TCGA patient cohorts, RNA activity of the Transdifferentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C16orf74, SMAD3, and CREG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transdifferentiation activity versus C16orf74 in HNSC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	C16orf74 →	+0.948	+0.092	<.001	.001	3	4
HNSC	SMAD3 →	+0.921	+0.101	<.001	<.001	3	4
LSCC	CREG2 →	+0.504	+0.137	.002	.006	3	4
HNSC	CD9 →	+1.233	+0.090	.002	.002	3	3
HNSC	TMOD3 →	+0.590	+0.101	.009	.001	3	3
HNSC	ANKK1 →	+0.695	+0.101	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060290 vs C16orf74 — HNSC

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