Transdifferentiation

Across TCGA cell cohorts, RNA activity of the Transdifferentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEUROG3, GATA4, and SMAD3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEUROG3 grouped by Transdifferentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NEUROG3 →	-0.282	-0.909	.001	.003	2	13
UPPER_AERODIGESTIVE_TRACT	GATA4 →	-0.252	-2.046	.001	<.001	3	11
OVARY	SMAD3 →	-0.237	-1.696	<.001	<.001	3	7
LARGE_INTESTINE	INSM1 →	-0.225	-1.493	.002	<.001	3	7
LIVER	ASCL2 →	-0.290	-1.770	.004	<.001	3	5
PANCREAS	CRK →	+0.282	+0.992	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEUROG3 by Transdifferentiation activity — SKIN

Explore this box plot interactively →