Transdifferentiation

Across TCGA cell cohorts, RNA activity of the Transdifferentiation pathway is significantly associated with the total protein of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Lck, IRS1, and 4E-BP1_pT37_T46, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transdifferentiation activity versus Lck in BLOOD_Leukemia (Pearson r = 0.81).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Lck →	+1.239	+0.389	.003	.041	2	2
BLOOD_Leukemia	IRS1 →	-0.588	-0.462	.020	.032	2	1
BLOOD_Leukemia	4E-BP1_pT37_T46 →	+0.617	+0.389	.028	.041	2	1
SKIN	mTOR →	-0.468	-0.167	.024	.021	1	2
SKIN	XRCC1 →	-0.263	-0.167	.014	.021	1	2
SKIN	YAP_pS127 →	+1.531	+0.167	.024	.021	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060290 vs Lck — BLOOD_Leukemia

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