Epithelial cilium movement involved in determination of left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Epithelial cilium movement involved in determination of left/right asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR54, CETN2, and TTC21B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cilium movement involved in determination of left/right asymmetry activity versus WDR54 in UCEC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR54 →	+0.590	+0.200	<.001	<.001	3	8
UCEC	CETN2 →	+0.468	+0.184	<.001	<.001	3	8
UCEC	TTC21B →	+0.316	+0.160	<.001	<.001	3	7
BRCA	WDR19 →	+0.518	+0.103	<.001	<.001	3	7
UCEC	WDR35 →	+0.446	+0.200	<.001	<.001	3	7
UCEC	DNAL4 →	+0.568	+0.174	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060287 vs WDR54 — UCEC

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