Epithelial cilium movement involved in determination of left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Epithelial cilium movement involved in determination of left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR87, RFX3, and SEC63P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cilium movement involved in determination of left/right asymmetry activity versus GPR87 in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPR87 →	-0.475	-0.294	.006	.005	3	4
LSCC	RFX3 →	+0.462	+0.317	<.001	<.001	3	4
OV	SEC63P1 →	-1.122	-0.783	<.001	.001	3	4
OV	OR1I1 →	-0.020	-0.753	<.001	.005	3	4
BRCA	STOX1 →	+1.109	+0.481	<.001	.001	3	4
OV	HMGN1P30 →	-1.675	-0.670	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060287 vs GPR87 — LSCC

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