Epithelial cilium movement involved in determination of left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Epithelial cilium movement involved in determination of left/right asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZC3H13_S1210, SHANK3_S679, and TRIM24_S110, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cilium movement involved in determination of left/right asymmetry activity versus ZC3H13_S1210 in HNSC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZC3H13_S1210 →	+0.630	+0.142	<.001	.002	3	3
LSCC	SHANK3_S679 →	+1.103	+1.049	.003	<.001	3	3
LSCC	TRIM24_S110 →	+1.456	+0.544	<.001	<.001	3	3
LSCC	PKN3_T718 →	+0.465	+0.402	<.001	<.001	3	3
PDAC	SNIP1_S52 →	+0.543	+0.313	.008	.001	2	4
OV	GIGYF1_S157 →	+0.792	+0.653	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060287 vs ZC3H13_S1210 — HNSC

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