Epithelial cilium movement involved in determination of left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Epithelial cilium movement involved in determination of left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN14, TRIP10, and C1orf115, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN14 grouped by Epithelial cilium movement involved in determination of left/right asymmetry-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TSPAN14 →	-1.285	-0.720	<.001	.009	3	3
SKIN	TRIP10 →	+0.685	+0.756	.002	.005	3	3
SKIN	C1orf115 →	-1.511	-0.745	.003	.006	3	3
SKIN	ERAP2 →	+2.065	+0.733	<.001	.007	3	3
SKIN	CCL5 →	+1.159	+0.785	.003	.003	3	3
STOMACH	CKMT1A →	-2.581	-0.399	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN14 by Epithelial cilium movement involved in determination of left/right asymmetry activity — SKIN

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