Epithelial cilium movement involved in determination of left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Epithelial cilium movement involved in determination of left/right asymmetry pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP20, PITPNM2, and GPI, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMP20 grouped by Epithelial cilium movement involved in determination of left/right asymmetry-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MMP20 →	+0.175	+0.811	.002	<.001	3	4
SKIN	PITPNM2 →	+0.178	+0.903	.002	.003	3	3
OVARY	GPI →	-0.196	-1.027	<.001	<.001	3	3
LIVER	ZNF687 →	+0.238	+1.451	.001	<.001	3	3
OVARY	CD1E →	-0.208	-0.961	.006	.001	3	3
BREAST	KDM5A →	-0.154	-0.559	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMP20 by Epithelial cilium movement involved in determination of left/right asymmetry activity — OVARY

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