Embryonic skeletal joint morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic skeletal joint morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTKN, SMARCD2, and DNAJA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTKN grouped by Embryonic skeletal joint morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RTKN →	+1.401	+1.035	<.001	.002	3	5
STOMACH	SMARCD2 →	+0.557	+1.040	.004	.002	3	4
LUNG_NSCLC_LUAD	DNAJA1 →	-0.656	-0.943	.001	<.001	3	4
KIDNEY	KHDRBS3 →	-1.354	-1.009	.002	.003	3	4
LIVER	DTX4 →	+1.838	+0.509	.005	.002	3	4
URINARY_TRACT	PTK2B →	+2.989	+1.767	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTKN by Embryonic skeletal joint morphogenesis activity — STOMACH

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