Negative regulation of respiratory burst

Across TCGA cell cohorts, RNA activity of the Negative regulation of respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB14, TENT2, and ZNF724, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB14 grouped by Negative regulation of respiratory burst-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB14 →	+0.503	+0.275	.001	.001	3	4
BONE	TENT2 →	+0.860	+0.365	.003	.006	3	4
OVARY	ZNF724 →	+0.921	+0.184	.001	.003	3	4
OVARY	ZNF808 →	+0.865	+0.191	.005	.006	3	4
LARGE_INTESTINE	SLC10A7 →	-0.923	-0.336	<.001	.001	3	4
LARGE_INTESTINE	C12orf56 →	-1.728	-0.258	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB14 by Negative regulation of respiratory burst activity — BONE

Explore this box plot interactively →