Positive regulation of respiratory burst

Across TCGA cell cohorts, RNA activity of the Positive regulation of respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTSS2, CUZD1, and PRKG1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of respiratory burst activity versus MTSS2 in BLOOD_Leukemia (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MTSS2 →	-3.612	-0.398	.009	.001	3	2
BLOOD_Myeloma	CUZD1 →	-0.750	-0.181	.001	.002	3	2
BLOOD_Myeloma	PRKG1 →	-1.885	-0.181	.004	.002	3	2
BLOOD_Leukemia	AKIRIN2 →	+1.065	+0.316	.008	.006	3	2
BLOOD_Leukemia	WDR19 →	+0.969	+0.267	.002	.003	3	2
BLOOD_Leukemia	FAM114A1 →	+0.637	+0.258	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060267 vs MTSS2 — BLOOD_Leukemia

Explore this scatter interactively →