Negative regulation of respiratory burst involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Negative regulation of respiratory burst involved in inflammatory response pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CKAP4, NBEAL2, and KIF26B_S1084, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of respiratory burst involved in inflammatory response activity versus CKAP4 in CCRCC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CKAP4 →	+0.343	+0.071	.009	.001	3	4
CCRCC	NBEAL2 →	+0.155	+0.055	.003	.002	3	4
UCEC	KIF26B_S1084 →	+0.833	+0.095	.008	.009	3	4
UCEC	MIA3 →	+0.322	+0.078	<.001	<.001	3	4
BRCA	VWA5A →	+0.465	+0.060	.001	.002	3	4
BRCA	CHRAC1 →	-0.446	-0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060266 vs CKAP4 — CCRCC

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