Negative regulation of respiratory burst involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Negative regulation of respiratory burst involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRN, PBXIP1, and TPP1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of respiratory burst involved in inflammatory response activity versus GRN in BLOOD_Lymphoma (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GRN →	+1.830	+0.160	<.001	<.001	3	20
LUNG_NSCLC_LUSC	PBXIP1 →	+1.847	+0.055	<.001	.002	3	16
STOMACH	TPP1 →	+1.343	+0.106	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	STAT2 →	+1.939	+0.084	<.001	<.001	3	16
BREAST	TMUB2 →	+1.078	+0.141	<.001	<.001	3	16
KIDNEY	PSAP →	+1.645	+0.156	.002	.004	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060266 vs GRN — BLOOD_Lymphoma

Explore this scatter interactively →