Regulation of respiratory burst involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Regulation of respiratory burst involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP10, CD3D, and CD3E, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory burst involved in inflammatory response activity versus DUSP10 in LIHC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	DUSP10 →	+1.129	+0.070	<.001	<.001	3	18
UVM	CD3D →	-2.180	-0.126	<.001	<.001	3	15
UVM	CD3E →	-2.110	-0.121	<.001	<.001	3	15
THYM	TRBV28 →	-2.557	-0.050	<.001	<.001	3	15
KICH	PTGR1 →	-0.953	-0.069	.005	.005	1	16
UVM	CD2 →	-2.131	-0.124	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060264 vs DUSP10 — LIHC

Explore this scatter interactively →