Regulation of respiratory burst involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Regulation of respiratory burst involved in inflammatory response pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RETREG3_S320, SAMSN1_S23, and STK10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory burst involved in inflammatory response activity versus RETREG3_S320 in HNSC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RETREG3_S320 →	+0.380	+0.130	.005	.003	3	5
UCEC	SAMSN1_S23 →	-0.558	-0.094	.001	.008	3	5
GBM	STK10 →	-0.375	-0.109	<.001	<.001	3	5
GBM	CORO1A →	-0.501	-0.106	<.001	<.001	3	5
HNSC	CYTH4 →	-0.496	-0.143	<.001	.001	3	5
GBM	FGR →	-0.779	-0.148	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060264 vs RETREG3_S320 — HNSC

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