Regulation of respiratory burst involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Regulation of respiratory burst involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CADM4, ZNF365, and TMEM171, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory burst involved in inflammatory response activity versus CADM4 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CADM4 →	-1.395	-0.305	.006	.009	3	2
LUNG_NSCLC_LUAD	ZNF365 →	+1.127	+0.281	.003	.007	3	2
LUNG_NSCLC_LUAD	TMEM171 →	+1.344	+0.276	.001	.008	3	2
LUNG_NSCLC_LUAD	DCST1 →	-0.341	-0.308	.008	.003	3	2
LUNG_NSCLC_LUAD	STPG3 →	-0.682	-0.306	.006	.003	3	2
LUNG_NSCLC_LUAD	SCX →	-1.219	-0.385	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060264 vs CADM4 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →