Regulation of respiratory burst

Across TCGA cell cohorts, RNA activity of the Regulation of respiratory burst pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH9, RAC2, and STK17A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory burst activity versus MYH9 in LIVER (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MYH9 →	+2.030	+0.400	<.001	<.001	3	6
PANCREAS	RAC2 →	+2.951	+0.396	.001	<.001	3	6
BLOOD_Leukemia	STK17A →	+1.148	+0.151	<.001	.001	3	6
LIVER	FLI1 →	+2.448	+0.378	<.001	<.001	3	6
LIVER	BMPER →	+4.517	+0.438	<.001	.004	3	6
SOFT_TISSUE	NCALD →	-4.877	-0.393	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060263 vs MYH9 — LIVER

Explore this scatter interactively →