Regulation of feeding behavior

Across TCGA patient cohorts, RNA activity of the Regulation of feeding behavior pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAA25, SELP, and SPARCL1_T419, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of feeding behavior activity versus NAA25 in BRCA (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NAA25 →	-0.236	-0.034	.006	.001	3	4
LSCC	SELP →	+0.387	+0.041	.004	.003	3	3
LSCC	SPARCL1_T419 →	+0.835	+0.077	<.001	<.001	3	3
LSCC	STK17B_S10 →	+0.568	+0.035	.003	.003	3	3
LSCC	BCL9L_S88 →	-0.312	-0.039	.005	.003	3	3
LSCC	VPS41 →	+0.170	+0.034	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060259 vs NAA25 — BRCA

Explore this scatter interactively →