Regulation of feeding behavior

Across TCGA patient cohorts, RNA activity of the Regulation of feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGPAT4, PABPC5-AS1, and SMIM14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of feeding behavior activity versus AGPAT4 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AGPAT4 →	+0.543	+0.338	.001	.002	3	4
GBM	PABPC5-AS1 →	+0.782	+0.547	<.001	<.001	3	4
UCEC	SMIM14 →	+0.659	+0.770	.003	.001	3	3
UCEC	RN7SL521P →	-0.455	-0.587	<.001	<.001	3	3
BRCA	EVA1A →	+0.535	+0.239	.003	.007	3	3
BRCA	SLC38A5 →	+0.797	+0.344	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060259 vs AGPAT4 — BRCA

Explore this scatter interactively →