Negative regulation of glial cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of glial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLG, AMBP, and GSPT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glial cell proliferation activity versus PLG in PDAC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLG →	+0.482	+0.049	.002	.003	3	6
OV	AMBP →	+0.528	+0.062	.002	.001	3	6
BRCA	GSPT1 →	-0.242	-0.042	.004	.008	3	5
CCRCC	C6 →	+0.562	+0.050	.001	.001	3	5
LSCC	C8A →	+0.331	+0.053	.002	.008	2	6
PDAC	C8B →	+0.421	+0.046	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060253 vs PLG — PDAC

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