Negative regulation of glial cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of glial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLI1, RCAN2, and GNG7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glial cell proliferation activity versus FLI1 in BRCA (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FLI1 →	-0.576	-0.600	.001	.001	3	5
HNSC	RCAN2 →	-0.983	-0.629	<.001	.001	3	5
COAD	GNG7 →	-0.606	-0.680	<.001	<.001	3	5
HNSC	SPR →	+0.887	+0.518	<.001	.002	3	4
HNSC	BORA →	+0.647	+0.595	<.001	<.001	3	4
COAD	DIAPH3 →	+0.540	+0.700	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060253 vs FLI1 — BRCA

Explore this scatter interactively →