Negative regulation of glial cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of glial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGF2BP2, TFAP4, and AMBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glial cell proliferation activity versus IGF2BP2 in BREAST (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IGF2BP2 →	-3.561	-0.399	<.001	.006	3	5
OESOPHAGUS	TFAP4 →	-1.018	-0.271	.001	.004	2	6
LIVER	AMBP →	+5.663	+0.291	.001	.009	3	4
BREAST	TRABD2A →	-1.490	-0.197	.008	.002	3	4
BONE	KDSR →	-3.387	-0.571	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CERS2 →	+0.810	+0.286	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060253 vs IGF2BP2 — BREAST

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