Positive regulation of glial cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of glial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNC13D, THEMIS2_T593, and ZYX_S344, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell proliferation activity versus UNC13D in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UNC13D →	+0.389	+0.047	.004	.001	3	8
BRCA	THEMIS2_T593 →	+0.853	+0.052	<.001	<.001	3	8
CCRCC	ZYX_S344 →	+0.691	+0.080	<.001	<.001	3	8
GBM	CD14 →	+0.546	+0.055	<.001	<.001	3	8
LSCC	PPP1R18_S195 →	+0.606	+0.063	<.001	<.001	3	8
LSCC	PPP1R18_S224 →	+0.510	+0.047	.002	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060252 vs UNC13D — OV

Explore this scatter interactively →