Positive regulation of glial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of glial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJD3, TRIB2, and GBE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GJD3 grouped by Positive regulation of glial cell proliferation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GJD3 →	+0.729	+1.341	.001	.001	3	6
OVARY	TRIB2 →	-2.464	-1.322	<.001	<.001	3	4
LARGE_INTESTINE	GBE1 →	-0.642	-0.598	.006	.003	3	4
LUNG_NSCLC_LUAD	ZPR1 →	+0.613	+0.806	.006	.004	3	3
LUNG_NSCLC_LUAD	TRAF2 →	+0.405	+0.783	.005	<.001	3	3
LUNG_NSCLC_LUAD	ARMC10 →	-0.459	-0.621	<.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GJD3 by Positive regulation of glial cell proliferation activity — BONE

Explore this box plot interactively →