Positive regulation of glial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of glial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B9D1, VPS16, and PABPC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glial cell proliferation activity versus B9D1 in PANCREAS (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	B9D1 →	+1.081	+0.281	<.001	<.001	3	4
BREAST	VPS16 →	-0.764	-0.212	.003	.001	3	3
BLOOD_Leukemia	PABPC4 →	+0.648	+0.889	.001	.008	3	3
BONE	PLEKHF2 →	-0.877	-0.310	.001	<.001	3	3
BONE	C5orf22 →	+0.678	+0.280	.008	.002	3	3
BLOOD_Myeloma	INHBC →	+1.702	+0.389	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060252 vs B9D1 — PANCREAS

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