Regulation of glial cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of glial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R18_S224, CD14, and C1QB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glial cell proliferation activity versus PPP1R18_S224 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPP1R18_S224 →	+0.647	+0.065	<.001	<.001	3	7
CCRCC	CD14 →	+0.426	+0.045	<.001	.003	3	7
CCRCC	C1QB →	+0.546	+0.045	<.001	<.001	3	6
BRCA	KCNAB2 →	+0.361	+0.029	<.001	<.001	3	6
BRCA	AP1M2 →	-0.387	-0.038	.001	<.001	3	6
BRCA	MARCKS_S101 →	+0.545	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060251 vs PPP1R18_S224 — LUAD

Explore this scatter interactively →